Anaplastic lymphoma kinase (ALK) gene rearrangements

Last revised by Dr Yuranga Weerakkody on 27 Aug 2021

Anaplastic lymphoma kinase (ALK) gene rearrangements are known to occur in association with several tumors. The genes code for an enzyme called anaplastic lymphoma kinase (ALK) or ALK tyrosine kinase receptor (also known as CD246) which is thought to play a role in brain development and exerts its effects on specific neurons in the nervous system. Rearrangements could result in anaplastic lymphoma kinase-1 (ALK-1) protein expression.

The key tumors associated with these rearrangements include:

It is also described in association with:

Clinical importance

Useful in determining the suitability of ALK-1 inhibitor therapy (e.g. crizotinib).

See also

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